TYROSINE KINASE INHIBITORS REGULATE SEROTONIN UPTAKE IN PLATELETS (VOL 280, PG R5, 1995)

被引：2

作者：

HELMESTE, DM ^{[1
]}

TANG, SW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,IRVINE MED CTR,DEPT PSYCHIAT,ORANGE,CA 92668

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 286卷 / 01期

关键词：

GENISTEIN; ERBSTATIN ANALOG; CA2+;

D O I：

10.1016/0014-2999(95)00553-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate. Binding studies indicated that uptake inhibition did not correlate with direct binding of these inhibitors to the transporter. Chelation of mobilizable intracellular Ca2+ did not inhibit the effects of genistein on uptake. These results suggest a more direct, non-Ca2+ mediated effect of tyrosine kinase inhibitors on uptake.

引用

页码：113 / 113

页数：1

共 50 条

[21] 1ST CAROLUS-MAGNUS SUMMER SCHOOL ON PLASMA PHYSICS (VOL 25, PG R5, 1994)
ROGISTER, AL
FUSION TECHNOLOGY, 1994, 25 (03): : 368 - 368
[22] Monoclonal antibody R5 for detection of putatively coeliac-toxic gliadin peptides (vol 222, pg 78, 2006)
Kahlenberg, F
Sanchez, D
Lachmann, I
Tuckova, L
Tlaskalova, H
Méndez, E
Mothes, T
EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2006, 222 (5-6) : 743 - 743
[23] Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors (vol 5, pg 227, 2008)
Csoka, A.
Bahrick, A.
Mehtonen, O. P.
JOURNAL OF SEXUAL MEDICINE, 2008, 5 (12): : 2977 - 2977
[24] Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans (vol 9, pg 109, 2008)
Ayzenberg, Ilya
Obermann, Mark
Leineweber, Kirsten
Franke, Leonora
Yoon, Min-Suk
Diener, Hans-Christoph
Katsarava, Zaza
JOURNAL OF HEADACHE AND PAIN, 2008, 9 (03): : 195 - 195
[25] Why have Tyrosine Kinase Inhibitors failed in the adjuvant Situation or can Checkpoint Inhibitors make more Sense? (vol 17, pg 313, 2020)
Krege, Susanne
UROLOGE, 2020, 59 (04): : 488 - 488
[26] Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors (vol 100, pg 585, 2002)
Liao
BLOOD, 2002, 100 (08) : 2696 - 2696
[27] Microarray analysis reveals strategies of Tribolium castaneum larvae to compensate for cysteine and serine protease inhibitors, (vol 5, pg 280, 2010)
Oppert, Brenda
Elpidina, Elena N.
Toutges, Michelle
Mazumdar-Leighton, Sue
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS, 2011, 6 (02): : 235 - 235
[28] Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor (vol 377, pg 32, 1995)
Hatada, Marcos H.
Lu, Xiaode
Laird, Ellen R.
Green, Jeremy
Morgenstern, Jay P.
Lou, Meizhen
Marr, Chris S.
Phillips, Thomas B.
Ram, Mary K.
Theriault, Kelly
Zoller, Mark J.
Karas, Jennifer L.
NATURE, 2007, 446 (7137) : 824 - 824
[29] The Importance of Facts and the Role of Academic Publishers in Today's World-A Publisher's View (vol 30, pg R5, 2017)
Schiff, Daniel
FACIAL PLASTIC SURGERY, 2017, 33 (02) : VII - VII
[30] Sensitivity analysis of EGFR L861Q mutation to six tyrosine kinase inhibitors (vol 24, pg 1975, 2022)
Liu, Chang
Wang, Zhenxing
Liu, Qian
Wu, Guangyao
Chu, Chunhong
Li, Lanxin
An, Lei
Duan, Shaofeng
CLINICAL & TRANSLATIONAL ONCOLOGY, 2024, 26 (02): : 557 - 557

← 1 2 3 4 5 →