TYROSINE KINASE INHIBITORS REGULATE SEROTONIN UPTAKE IN PLATELETS (VOL 280, PG R5, 1995)

被引：2

作者：

HELMESTE, DM ^{[1
]}

TANG, SW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,IRVINE MED CTR,DEPT PSYCHIAT,ORANGE,CA 92668

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 286卷 / 01期

关键词：

GENISTEIN; ERBSTATIN ANALOG; CA2+;

D O I：

10.1016/0014-2999(95)00553-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate. Binding studies indicated that uptake inhibition did not correlate with direct binding of these inhibitors to the transporter. Chelation of mobilizable intracellular Ca2+ did not inhibit the effects of genistein on uptake. These results suggest a more direct, non-Ca2+ mediated effect of tyrosine kinase inhibitors on uptake.

引用

页码：113 / 113

页数：1

共 50 条

[11] Outcome of metastatic GIST in the era before tyrosine kinase inhibitors (vol 14, pg 3027)
Gold, Jason S.
van der Zwan, Sanne M.
Goenen, Mithat
Maki, Robert G.
Singer, Samuel
Brennan, Murray F.
Antonescu, Cristina R.
De Matteo, Ronald P.
ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (10) : 3027 - 3027
[12] Tyrosine Kinase Inhibitors and Diabetes A Novel Treatment Paradigm? (vol 26, pg 643, 2015)
Fountas, Athanasios
Diamantopoulos, Leonidas-Nikolaos
Tsatsoulis, Agathocles
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2016, 27 (01): : 65 - 65
[13] There Is No Face-to-Face Partition of R5 into Acute Simplices (vol 36, pg 381, 2006)
Krizek, M.
DISCRETE & COMPUTATIONAL GEOMETRY, 2010, 44 (02) : 484 - 485
[14] Electron drift mobility in porous TiO2 (anatase) (vol 165, pg R5, 1998)
Dittrich, T
Lebedev, EA
Weidmann, J
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 1998, 167 (01): : R9 - R9
[15] NEW INDOLE-DERIVATIVES AS POTENT AND SELECTIVE SEROTONIN UPTAKE INHIBITORS (VOL 36, PG 1194, 1993)
MALLERON, JL
GUEREMY, C
MIGNAGI, S
PEYRONEL, JF
TRUCHON, A
BLANCHARD, JC
DOBLE, A
LADURON, P
PIOT, O
ZUNDEL, JL
BETSCHART, J
CANARD, H
CHAILLOU, P
FERRIS, O
HUON, C
JUST, B
KERPHIRIQUE, R
MARTIN, B
MOUTON, P
RENAUDON, A
SZMIGEL, JC
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (15) : 2242 - 2242
[16] Syk tyrosine kinase required for mouse viability and B-cell development (vol 378, pg 303, 1995)
Cheng, AM
Rowley, B
Pao, W
Hayday, A
Bolen, JB
Pawson, T
NATURE, 1996, 379 (6566) : 657 - 657
[17] Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis (vol 56, pg 9693, 2013)
Zhang, Weihe
McIver, Andrew L.
Stashko, Michael A.
DeRyckere, Deborah
Branchford, Brian R.
Hunter, Debra
Kireev, Dmitri
Miley, Michael J.
Norris-Drouin, Jacqueline
Stewart, Wendy M.
Lee, Minjung
Sather, Susan
Zhou, Yingqiu
Di Paola, Jorge A.
Machius, Mischa
Janzen, William P.
Earp, H. Shelton
Graham, Douglas K.
Frye, Stephen V.
Wang, Xiaodong
JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (16) : 7142 - 7142
[18] Bruton's tyrosine kinase inhibitors in chronic lymphocytic leukemia and lymphoma (vol 14, pg 543 , 2016)
Varma, Gaurav
Johnson, Tyler P.
Advani, Ranjana H.
CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, 2016, 14 (09) : 728 - 728
[19] G-PROTEIN-COUPLED CHEMOATTRACTANT RECEPTORS REGULATE LYN TYROSINE KINASE-CENTER-DOT-SHC ADAPTER PROTEIN SIGNALING COMPLEXES (VOL 270, PG 19969, 1995)
PTASZNIK, A
TRAYNORKAPLAN, A
BOKOCH, GM
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) : 24622 - 24622
[20] Challenges associated with the emergence of adenovirus type 14 at US Military Training Centers (vol 173, pg R5, 2008)
Bunning, Michel
Lyons, Arthur
Russell, Kevin
Faix, Dennis
Blaessing, Carl
Johns, Maj Natalie
Gaydos, Joel
MILITARY MEDICINE, 2008, 173 (09) : 824 - 824

← 1 2 3 4 5 →