IDENTIFICATION OF THE PROTECTIVE 44-KILODALTON RECOMBINANT ANTIGEN OF EHRLICHIA-RISTICII

被引：1

作者：

SHANKARAPPA, B ^{[1
]}

DUTTA, SK ^{[1
]}

MATTINGLYNAPIER, B ^{[1
]}

机构：

[1] UNIV MARYLAND, VIRGINIA MARYLAND REG COLL VET MED, COLLEGE PK, MD 20742 USA

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 02期

关键词：

D O I：

10.1128/IAI.60.2.612-617.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective studies were conducted with mice by using recombinantly produced antigens, polyacrylamide gel electrophoresis-fractionated antigens, and a monoclonal antibody specific to the 28-kDa antigen of Ehrlichia risticii. Analysis of E. risticii-infected cell culture used as the challenge inoculum indicated an inverse relationship between the progression of cell culture infection and the infective capability of E. risticii for mice. A recombinant 44-kDa antigen was found to protect mice considerably against challenge infection, while the monoclonal antibody and fractionated antigens were not protective. A potentiation of protection was observed when the recombinant 44-kDa antigen was combined with the recombinant 70-kDa antigen and used for mouse immunization.

引用

页码：612 / 617

页数：6

共 23 条

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ZHANG, YY
LI, E
JACKSON, TFHG
ZHANG, TH
GATHIRAM, V
STANLEY, SL
JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (11) : 2788 - 2792
[22] Intranasal immunization with recombinant Ascaris suum 14-kilodalton antigen coupled with cholera toxin B subunit induces protective immunity to A-suum infection in mice
Tsuji, N
Suzuki, K
Kasuga-Aoki, H
Matsumoto, Y
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Ishiwata, K
Isobe, T
INFECTION AND IMMUNITY, 2001, 69 (12) : 7285 - 7292
[23] IDENTIFICATION OF A 68-KILODALTON OUTER-MEMBRANE PROTEIN AS THE MAJOR PROTECTIVE ANTIGEN OF BORDETELLA-BRONCHISEPTICA BY USING SPECIFIC-PATHOGEN-FREE PIGLETS
KOBISCH, M
NOVOTNY, P
INFECTION AND IMMUNITY, 1990, 58 (02) : 352 - 357

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