IDENTIFICATION OF THE PROTECTIVE 44-KILODALTON RECOMBINANT ANTIGEN OF EHRLICHIA-RISTICII

被引：1

作者：

SHANKARAPPA, B ^{[1
]}

DUTTA, SK ^{[1
]}

MATTINGLYNAPIER, B ^{[1
]}

机构：

[1] UNIV MARYLAND, VIRGINIA MARYLAND REG COLL VET MED, COLLEGE PK, MD 20742 USA

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 02期

关键词：

D O I：

10.1128/IAI.60.2.612-617.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective studies were conducted with mice by using recombinantly produced antigens, polyacrylamide gel electrophoresis-fractionated antigens, and a monoclonal antibody specific to the 28-kDa antigen of Ehrlichia risticii. Analysis of E. risticii-infected cell culture used as the challenge inoculum indicated an inverse relationship between the progression of cell culture infection and the infective capability of E. risticii for mice. A recombinant 44-kDa antigen was found to protect mice considerably against challenge infection, while the monoclonal antibody and fractionated antigens were not protective. A potentiation of protection was observed when the recombinant 44-kDa antigen was combined with the recombinant 70-kDa antigen and used for mouse immunization.

引用

页码：612 / 617

页数：6

共 23 条

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AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 72 (04): : 458 - 464
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JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) : 3349 - 3358
[15] IDENTIFICATION OF A 68-KILODALTON PROTECTIVE PROTEIN ANTIGEN FROM BORDETELLA-BRONCHISEPTICA
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INFECTION AND IMMUNITY, 1985, 47 (03) : 744 - 751
[16] Identification of the gene encoding a 38-kilodalton immunogenic and protective antigen of Streptococcus suis
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CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (04) : 484 - 490
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DiPietrantonio, AM
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (02) : 351 - 355
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JOURNAL OF CLINICAL MICROBIOLOGY, 2023, 61 (10)
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