CRYSTAL AND MOLECULAR-STRUCTURES OF 1-(2-ETHYLOXYCARBONYLO PROPAN-2-YLAMINO)-3-(1-NAPTHYLOXY) PROPAN-2-OL-HYDROCHLORIDE (1) (C19H26NO4CL) AND 1-(2-ISOPROPYLOXYCARBONYLO-PROPAN-2-YLAMINO)-3-(1-NAPTHYLOXY) PROPAN-2-OL HYDROCHLORIDE (2) (C20H28NO4CL)

被引：4
|
作者：
BUJACZ, GD [1 ]
WIECZOREK, MW [1 ]
GALAS, E [1 ]
ZJAWIONY, J [1 ]
WOJCIECHOWSKA, A [1 ]
机构：
[1] TECH UNIV LODZ,INST ORGAN CHEM,PL-90924 LODZ,POLAND
来源：
JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH | 1991年 / 21卷 / 03期
关键词：
D O I：
10.1007/BF01156087
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The crystal structures of two new beta-adrenergic antagonists, derivatives of propranolol, are shown in this paper. The space groups and unit-cell parameters are: compound 1 (C19H26NO4Cl): triclinic, space group P1, a = 6.420(1), b = 10.161(1), c = 15.823(1) angstrom, alpha = 82.47(1), beta = 84.16(1), gamma = 77.55(1)-degrees; compound 2 (C20H28NO4Cl): monoclinic, space group P2(1)/c, a = 6.460(1), b = 33.285(2), c = 10.120(1) angstrom, beta = 104.83(1)-degrees. The structures were solved by direct methods and refined with full-matrix least-squares techniques to R indices of 0.055 and 0.048, respectively. The -CH(OH)-CH2-NH-sections of the side chains show the conformation approximate to gauche.
引用
收藏
页码：341 / 352
页数：12
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