DIFFERENTIAL EXPRESSION OF GRANZYME-A AND GRANZYME-B PROTEASES AND THEIR SECRETION BY FRESH RAT NATURAL-KILLER-CELLS (NK) AND LYMPHOKINE-ACTIVATED KILLER-CELLS WITH NK PHENOTYPE (LAK-NK)

被引：41

作者：

VELOTTI, F ^{[1
]}

PALMIERI, G ^{[1
]}

DAMBROSIO, D ^{[1
]}

PICCOLI, M ^{[1
]}

FRATI, L ^{[1
]}

SANTONI, A ^{[1
]}

机构：

[1] CNR, INST BIOMED TECHNOL, ROME, ITALY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 04期

关键词：

D O I：

10.1002/eji.1830220426

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granzymes A-G are a family of serine proteases localized in the cytoplasmic granules of cytotoxic T lymphocytes (Masson, D. et al. Cell 1987. 49: 679) and granzyme A is secreted by T lymphocytes in response to antigenic stimulation. Granzyme A is also expressed by natural killer (NK) and lymphokine-activated killer (LAK) cells. Here we show that fresh rat NK cells constitutively express granzyme B and that granzyme A and granzyme B are differentially regulated in unstimulated NK cells vs. LAK cells with NK phenotype (LAK-NK cells). We also show that both granzymes A and B are secreted in a calcium-dependent manner, by NK and LAK-NK cells in response to stimuli which trigger NK cell functions.

引用

页码：1049 / 1053

页数：5

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