Expression Of Spontaneous Aggregation Of Erythrocytes In Patients With Arterial Hypertension With Hyperuricemia

The very wide prevalence of thrombosis in hypertensive patients with hyperuricemia is largely associated with dysfunction of their blood cells. The situation is aggravated by the high frequency of occurrence in the developed countries of a combination of arterial hypertension with hyperuricemia. In view of the largest abundance in the blood of red blood cells, the state of their aggregation is most significant for providing an aggregate state of blood. The aim of the work is to assess the degree of disruption of aggregation properties of erythrocytes in patients with hypertension with hyperuricemia. 41 patients with arterial hypertension of 1-2 degree with hyperuricemia of the second adulthood were examined. The control consisted of 26 clinically healthy people of the second adulthood. Biochemical, hematological and statistical methods of investigation were used. In patients, an excess of cholesterol in erythrocyte membranes was found in the study, a decrease in the level of total phospholipids in them and activation of lipid peroxidation in them. In patients, an excess of spontaneous aggregation of erythrocytes was found. This should be considered as a consequence of the lipid peroxidation, metabolic disturbances, increased spasm of blood vessels and changes in the ratio of biologically active substances in the blood of hypertensive hyperuricemia. The presence of hyperaggregation of erythrocytes in patients with arterial hypertension with hyperuricemia dramatically increases the risk of thrombosis, which can lead to a permanent disability they are fatal.