Expression Of Spontaneous Aggregation Of Erythrocytes In Patients With Arterial Hypertension With Type 2 Diabetes Mellitus

For patients with arterial hypertension with type 2 diabetes mellitus, hyperaggregation of blood cells is very characteristic. The prevalence in the developed countries of a combination of arterial hypertension with type 2 diabetes mellitus provides a high interest for researchers. Particular attention in this pathology attracts the aggregation of the most numerous population of blood cells - erythrocytes. The purpose of the study is to study the severity of aggregation properties of erythrocytes in patients with arterial hypertension with type 2 diabetes mellitus. 42 patients with arterial hypertension of 1-2 degrees and type 2 diabetes mellitus of the second adult age were examined. The control consisted of 26 healthy persons of the second adult age. Biochemical, hematological and statistical methods are applied. In patients, an increase in the cholesterol content in erythrocyte membranes was found, a decrease in total phospholipids in them and activation of lipid peroxidation in them. A high activity of spontaneous aggregation of erythrocytes was also noted in patients. The changes found in the examined category of patients should be considered as a consequence of metabolic abnormalities arising on the background of arterial hypertension and diabetes mellitus 2, expressed vasospasm and activation of lipid peroxidation. Patients with this contingent of vasopathy dramatically increased their risk of fatal thrombosis.