Spontaneous Aggregation Of Erythrocytes In Patients With Arterial Hypertension With Impaired Glucose Tolerance

As before, the prevalence of a combination of arterial hypertension with a violation of glucose tolerance persists in society. This combination is very dangerous vascular thrombosis. They are associated with the presence of hyperaggregation of blood cells in them. Because of the high incidence in the developed countries of the combination of arterial hypertension with abdominal obesity, it causes great interest among researchers. It is very important to evaluate in this category of patients the aspects of aggregation of the most numerous population of blood cells - erythrocytes. The aim of the work is to evaluate the aggregation potential of red blood cells in patients with arterial hypertension and impaired glucose tolerance. 49 patients with arterial hypertension of 1-2 degree with impaired glucose tolerance of the second adult age were examined. Control is represented by 26 healthy people of the same age. Biochemical, hematological and statistical methods of investigation have been applied. In patients in erythrocyte membranes, an excess of cholesterol was found and the total phospholipids in them decreased when lipid peroxidation processes were activated in them. High spontaneous aggregation of erythrocytes was also revealed in patients. The intensification of aggregating properties on erythrocytes found is a consequence of metabolic disturbances arising in arterial hypertension with impaired glucose tolerance and active lipid peroxidation in plasma. The vasopathy present in the examined patients sharply increased their risk of thrombosis leading to disability and death.