MORPHINE AND NOREPINEPHRINE-INDUCED ANTINOCICEPTION AT THE SPINAL LEVEL IS MEDIATED BY ADENOSINE

被引：28

作者：

YANG, SW

ZHANG, ZH

CHEN, JY

XIE, YF

QIAO, JT

DAFNY, N

机构：

[1] UNIV TEXAS, SCH MED, DEPT NEUROBIOL & ANAT, HOUSTON, TX 77025 USA

[2] SHANXI MED COLL, DEPT NEUROBIOL, TAIYUAN 030001, PEOPLES R CHINA

来源：

NEUROREPORT | 1994年 / 5卷 / 12期

关键词：

ADENOSINE; MORPHINE; SEROTONIN; NOREPINEPHRINE; AMINOPHYLLINE; ANTINOCICEPTION; SPINAL CORD;

D O I：

10.1097/00001756-199407000-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE purpose of this study was to examine whether adenosine or serotonin is involved in mediation of the antinociception produced by norepinephrine at the spinal cord level. Aminophylline, an adenosine receptor antagonist and naloxone given intrathecally (i.t.) were used to test the antinociception produced by i.t. norepinephrine, serotonin, morphine or the adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) by using the tail-flick assay in rats. It was observed that (1) aminophylline blocked the antinociception produced by norepinephrine, but exhibited no effect on the antinociception produced by serotonin, (2) aminophylline blocked the antinociception produced by morphine similarly to naloxone, (3) aminophylline blocked the antinociception produced by NECA and (4) naloxone failed to block the antinociception produced by NECA and serotonin. The results suggest that adenosine is involved in mediation of the norepinephrine-produced antinociception at the spinal level and that norepinephrine and adenosine may act in a sequential manner in norepinephrine-induced antinociception.

引用

页码：1441 / 1444

页数：4

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