Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy

被引：16
|
作者：
Zhang, YP
Lundeberg, T
Yu, LC [1 ]
机构：
[1] Peking Univ, Coll Life Sci, Dept Physiol, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
[3] Karolinska Inst, Dept Surg & Rehabil, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
来源：
BRAIN RESEARCH | 2000年 / 852卷 / 02期
基金：
中国国家自然科学基金;
关键词：
galanin; opioid; galantide; nociceptive test; mononeuropathy;
D O I：
10.1016/S0006-8993(99)02236-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The increased hind-paw withdrawal latency (HWL) to thermal stimulation and hind-paw withdrawal threshold (HWT) to mechanical stimulation induced by morphine were attenuated by intrathecal injection of 1 or 3 nmol, but not 0.3 nmol of the selective galanin antagonist galantide. The result indicated a possible interaction between galanin and opioids in the transmission of presumed nociceptive information in the spinal cord of rats with mononeuropathy. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：485 / 487
页数：3
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