Dimethyl 2,2 '-[Carbonylbis(azanediyl)](2S,2 ' S)-bis[3-(4-hydroxyphenyl)propanoate]

被引：0
|
作者：
Mancuso, Raffaella [1 ]
Gioia, Katia F. [1 ]
Piccionello, Antonio Palumbo [2 ]
Della Ca', Nicola [3 ]
Carfagna, Carla [4 ]
Gabriele, Bartolo [1 ]
机构：
[1] Univ Calabria, Dept Chem & Chem Technol, Lab Ind & Synthet Organ Chem, Via Pietro Bucci 12-C, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim Farmaceut, STEBICEF, Viale Sci Ed 17, I-90128 Palermo, Italy
[3] Univ Parma, Dept Chem Life Sci & Environm Sustainabil SCVSA, Parco Area Sci 17-A, I-43124 Parma, Italy
[4] Univ Bologna, Dept Ind Chem T Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy
来源：
MOLBANK | 2018年 / 01期
关键词：
carbonylation; palladium; L-tyrosine methyl ester; ureas;
D O I：
10.3390/M983
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The thus-far unknown ureic derivative dimethyl 2,2'-[carbonylbis(azanediyl)](2S,2'S)-bis[3-(4-hydroxyphenyl) propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L-tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 degrees C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO-air).
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页数：3
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