17-BETA-HYDROXYWORTMANNIN - A POTENT INHIBITOR OF BONE-RESORPTION AND PHOSPHATIDYLINOSITOL-3-KINASE

被引：16

作者：

DODGE, JA

BRYANT, HU

KIM, J

MATTER, WF

NORMAN, BH

SRINIVASAN, U

VLAHOS, CJ

SATO, M

机构：

[1] Lilly Research Laboratories Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00291-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-function studies on the natural product wortmannin have identified a 17 beta-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed.

引用

页码：1713 / 1718

页数：6

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