17-BETA-HYDROXYWORTMANNIN - A POTENT INHIBITOR OF BONE-RESORPTION AND PHOSPHATIDYLINOSITOL-3-KINASE

被引：16

作者：

DODGE, JA

BRYANT, HU

KIM, J

MATTER, WF

NORMAN, BH

SRINIVASAN, U

VLAHOS, CJ

SATO, M

机构：

[1] Lilly Research Laboratories Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00291-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-function studies on the natural product wortmannin have identified a 17 beta-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed.

引用

页码：1713 / 1718

页数：6

共 50 条

[21] Effect of alpelisib, a selective phosphatidylinositol-3-kinase inhibitor, on seizure development in a rat pentylenetetrazole model
Rostamkhani, A.
Mirazi, N.
Hosseini, A.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY, 2023, 74 (04): : 6473 - 6480
[22] A combination therapy of atypical protein kinase inhibitor and phosphatidylinositol-3-kinase inhibitor reduces multidrug resistance in renal cell carcinoma (RCC)
Khalid, Khandker Mohammad
CANCER RESEARCH, 2019, 79 (13)
[23] SURAMIN IS A POTENT INHIBITOR OF CALCEMIC HORMONE-INDUCED AND GROWTH FACTOR-INDUCED BONE-RESORPTION INVITRO
FARSOUDI, KH
PIETSCHMANN, P
CROSS, HS
PETERLIK, M
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1993, 264 (02): : 579 - 583
[24] Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans
Yue, Qin
Khojasteh, S. Cyrus
Cho, Sungjoon
Ma, Shuguang
Mulder, Teresa
Chen, John
Pang, Jodie
Ding, Xiao
Deese, Alan
Pellet, Jackson D.
Siebers, Nicholas
Joas, Lori
Salphati, Laurent
Ware, Joseph A.
XENOBIOTICA, 2021, 51 (07) : 796 - 810
[25] [3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors
Yu, Hongyi
Moore, Michael L.
Erhard, Karl
Hardwicke, Mary Ann
Lin, Hong
Luengo, Juan I.
McSurdy-Freed, Jeanelle
Plant, Ramona
Qu, Junya
Raha, Kaushik
Rominger, Cynthia M.
Schaber, Michael D.
Spengler, Michael D.
Rivero, Ralph A.
ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (02): : 230 - 234
[26] Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Heydarei, Mahshad
Mirazi, Naser
Hosseini, Abdolkarim
NEUROCHEMICAL JOURNAL, 2023, 17 (03) : 452 - 456
[27] Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
Naser Mahshad Heydarei
Abdolkarim Mirazi
Neurochemical Journal, 2023, 17 : 452 - 456
[28] Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks
Ihara, Makoto
Shichijo, Kazuko
Takeshita, Satoshi
Kudo, Takashi
JOURNAL OF RADIATION RESEARCH, 2020, 61 (02) : 171 - 176
[29] ROLE OF PHOSPHATIDYLINOSITOL-3-KINASE IN INSULIN-RECEPTOR SIGNALING - STUDIES WITH INHIBITOR, LY294002
SANCHEZMARGALET, V
GOLDFINE, ID
VLAHOS, CJ
SUNG, CK
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (02) : 446 - 452
[30] A potent antagonist of αvβ3 integrin is a powerful inhibitor of bone resorption in vivo
Rodan, SB
Duong, LT
Duggan, ME
Fisher, JE
Gentile, MA
Fernandez-Metzler, C
Halczenko, W
Hartman, GD
Hutchinson, JH
Leu, C
Lipfert, L
Nagy, RM
Pennypacker, B
Prueksaritanont, T
Seedor, JG
Wesolowski, G
Kimmel, DB
Rodan, GA
JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 : S198 - S198

← 1 2 3 4 5 →