RANKING OF THE CYTOKINES INTERLEUKIN-1, TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-6 IN JUVENILE RHEUMATOID-ARTHRITIS

被引：0
|
作者：
RIEMANN, D
OPPERMANN, J
机构：
来源：
AKTUELLE RHEUMATOLOGIE | 1993年 / 18卷 / 03期
关键词：
D O I：
10.1055/s-2008-1047317
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-1, tumor necrosis factor and interleukin-6 are mediators of inflammation, produced by monocytes/macrophages and a multitude of other cells. There is a causal connection with the pathogenesis of juvenile rheumatoid arthritis. All cytokines are characterized by pleiotrope paracrine, autocrine and endocrine effects on target cells. This paper informs clinicians on the various and partly overlapping effects of the three cytokines mentioned above in relation to the persisting and self-perpetuating reactions of inflammation in juvenile rheumatoid arthritis. Additional mechanisms of regulation of the network of cytokines are described.
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页码：69 / 76
页数：8
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