INDUCTION OF MN-SUPEROXIDE DISMUTASE BY TUMOR-NECROSIS-FACTOR, INTERLEUKIN-1 AND INTERLEUKIN-6 IN HUMAN HEPATOMA-CELLS

被引：61
|
作者：
ONO, M
KOHDA, H
KAWAGUCHI, T
OHHIRA, M
SEKIYA, C
NAMIKI, M
TAKEYASU, A
TANIGUCHI, N
机构：
[1] UBE IND,UBE LAB,UBE 755,JAPAN
[2] OSAKA UNIV,SCH MED,DEPT BIOCHEM,OSAKA,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 03期
关键词：
D O I：
10.1016/0006-291X(92)91845-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase (Mn-SOD) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1. Both TNF and IL-1 enhanced the Mn-SOD production to the level of 30- to 40-fold. IL-6 also increased the enzyme protein to 2- to 3-fold of the basal level without any cell proliferative effect. A specific antibody against IL-6 almost completely inhibited the induction of Mn-SOD. IL-6, as well as TNF and IL-1, appears to play some role in the Mn-SOD protein expression in human hepatoma cells. © 1992.
引用
收藏
页码：1100 / 1107
页数：8
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