INTERACTION OF INTERLEUKIN-6, TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 DURING LISTERIA INFECTION

被引：0
|
作者：
LIU, Z
SIMPSON, RJ
CHEERS, C
机构：
[1] UNIV MELBOURNE, DEPT MICROBIOL, PARKVILLE, VIC 3052, AUSTRALIA
[2] LUDWIG INST CANC RES, JOINT PROT STRUCT LAB, PARKVILLE, VIC, AUSTRALIA
[3] WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC, AUSTRALIA
来源：
IMMUNOLOGY | 1995年 / 85卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Injected recombinant interleukin-6 (IL-6), tumour necrosis factor (TNF) and IL-1 all protect mice against experimental infection with Listeria monocy,togenes. We have therefore investigated the interaction of these cytokines during infection. Treatment with recombinant (r)IL-6 enhanced TNF production by spleen cells during the first 2 days of infection. Anti-TNF antibody could totally abolish the protective effect of rIL-6, while the optimal protective function of TNF could not be achieved when IL-6 was neutralized by anti-IL-6 antibody. IL-1 induced a high level of IL-6 in the serum a short time after its administration, and neutralization of IL-6 totally abolished the protective function of rIL-1. The results thus provide further evidence for the complexity of cytokine interaction.
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页码：562 / 567
页数：6
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