MUTAGENIC EFFECTS OF FERRIC NITRILOTRIACETATE (FE-NTA) ON V79 CHINESE HAMSTER-CELLS AND ITS INHIBITORY EFFECTS ON CELL-CELL COMMUNICATION

被引：18

作者：

NAKATSUKA, S ^{[1
]}

TANAKA, H ^{[1
]}

NAMBA, M ^{[1
]}

机构：

[1] KAWASAKI UNIV,SCH MED,DEPT PATHOL,KURASHIKI,OKAYAMA 70101,JAPAN

来源：

CARCINOGENESIS | 1990年 / 11卷 / 02期

关键词：

D O I：

10.1093/carcin/11.2.257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ferric nitrilotriacetate (Fe-NTA) induced dose- and time-dependent mutation of V79 Chinese hamster cells to 6-thioguanine resistance. It also caused dose-related inhibition of metabolic cooperation. However, no significant induction of chromosome aberrations was detected in cells treated with Fe-NTA up to 100 μg Fe/ml of the drug even after treatment for 3 days. Our results indicate that Fe-NTA has mutagenic effects on V79 cells and inhibitory effects on cell-cell communication, and these effects may contribute to NTA-Fe-induced neoplastic transformation of mammalian cells. © 1990 Oxford University Press.

引用

页码：257 / 260

页数：4

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