Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

被引：11
|
作者：
Oda, T [1 ]
机构：
[1] Kyoritsu Coll Pharmaceut Sci, Dept Pharmaceut Sci, Minato Ku, Tokyo 1028512, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 02期
关键词：
griseofulvin; 2 '-demethoxy-2 '-propoxygriseofulvin; microtubule; Chinese hamster V79 cells;
D O I：
10.1038/ja.2006.17
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2'-substitutive derivatives of griseofalvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2'-demethoxy-2' propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
引用
收藏
页码：114 / 116
页数：3
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