MUTAGENIC EFFECTS OF FERRIC NITRILOTRIACETATE (FE-NTA) ON V79 CHINESE HAMSTER-CELLS AND ITS INHIBITORY EFFECTS ON CELL-CELL COMMUNICATION

被引：18
|
作者：
NAKATSUKA, S [1 ]
TANAKA, H [1 ]
NAMBA, M [1 ]
机构：
[1] KAWASAKI UNIV,SCH MED,DEPT PATHOL,KURASHIKI,OKAYAMA 70101,JAPAN
来源：
CARCINOGENESIS | 1990年 / 11卷 / 02期
关键词：
D O I：
10.1093/carcin/11.2.257
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ferric nitrilotriacetate (Fe-NTA) induced dose- and time-dependent mutation of V79 Chinese hamster cells to 6-thioguanine resistance. It also caused dose-related inhibition of metabolic cooperation. However, no significant induction of chromosome aberrations was detected in cells treated with Fe-NTA up to 100 μg Fe/ml of the drug even after treatment for 3 days. Our results indicate that Fe-NTA has mutagenic effects on V79 cells and inhibitory effects on cell-cell communication, and these effects may contribute to NTA-Fe-induced neoplastic transformation of mammalian cells. © 1990 Oxford University Press.
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收藏
页码：257 / 260
页数：4
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