EFFECTS OF ANTIOXIDANTS ON V79 CHINESE-HAMSTER CELLS TREATED WITH FERRIC NITRILOTRIACETATE

被引：0
|
作者：
TAKEHARA, Y
YOSHIOKA, T
NAMBA, M
机构：
[1] OKAYAMA UNIV, SCH MED, INST CANC RES, DEPT PATHOL, OKAYAMA 700, JAPAN
[2] KURASHIKI CTR ADULT DIS, MED SCI LAB, KURASHIKI 710, JAPAN
来源：
ACTA MEDICA OKAYAMA | 1990年 / 44卷 / 06期
关键词：
V79; CELLS; FE-NTA; ANTIOXIDANTS; CYTOTOXICITY; FREE RADICALS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The cytotoxic effects of ferric nitrilotriacetate (Fe-NTA) have been considered to be caused by free radicals produced by the drug. The present study was carried out to determine whether or not cytotoxic effects of Fe-NTA on cell growth and lipoperoxide formation of Chinese hamster cells were reduced by antioxidants. Using a spin trapping technique, we found that hydroxyl radical formation in the cells increased in the presence of Fe-NTA. Antioxidants, with the exception of superoxide dismutase, slightly inhibited production of the hydroxyl radical. Mannitol significantly reduced lipoperoxide formation, but other antioxidants did not. However, the growth inhibitory effects of Fe-NTA were not attenuated by these antioxidants. These results indicated that the cytotoxic effects of Fe-NTA may be mostly due to unknown factors other than oxygen free radicals.
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页码：287 / 291
页数：5
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