TRANSPLATIN BLOCKS VOLTAGE-DEPENDENT CALCIUM CURRENT IN ISOLATED COCHLEAR OUTER HAIR-CELLS BUT IS NOT OTOTOXIC IN-VIVO

被引：2
|
作者：
SAITO, T
YAMAMOTO, T
ZHANG, ZJ
YAMADA, T
MANABE, Y
SAITO, H
机构：
[1] Department of Otolaryngology, Fukui Medical School, Yoshida-gun, 910-11 Fukui, Matsuoka-cho
来源：
BRAIN RESEARCH | 1995年 / 697卷 / 1-2期
关键词：
TRANSPLATIN; CISPLATIN; OTOTOXICITY; COCHLEAR OUTER HAIR CELL; WHOLE-CELL PATCH-CLAMP; VOLTAGE-DEPENDENT CALCIUM CHANNEL; COMPOUND ACTION POTENTIAL;
D O I：
10.1016/0006-8993(95)00998-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of cisplatin (cis-DDP) and transplatin (trans-DDP) on the voltage-dependent calcium current (I-Ca) of outer hair cells isolated from the guinea pig cochlea were compared using the whole-cell patch-clamp technique. Both cis-DDP and trans-DDP blocked I-Ca in a concentration-dependent manner. Trans-DDP did not show ototoxicity or nephrotoxicity in vivo. From these results, it was suggested that the effect of cis-DDP on I-Ca does not directly lead to cell death.
引用
收藏
页码：276 / 279
页数：4
相关论文
共 50 条
  • [1] CISPLATIN BLOCKS VOLTAGE-DEPENDENT CALCIUM CURRENT IN DISSOCIATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA
    YAMAMOTO, T
    KAKEHATA, S
    SAITO, T
    SAITO, H
    AKAIKE, N
    BRAIN RESEARCH, 1994, 648 (02) : 296 - 298
  • [2] CISPLATIN BLOCKS DEPOLARIZATION-INDUCED CALCIUM ENTRY IN ISOLATED COCHLEAR OUTER HAIR-CELLS
    SAITO, T
    MOATAZ, R
    DULON, D
    HEARING RESEARCH, 1991, 56 (1-2) : 143 - 147
  • [3] ASYMMETRY IN VOLTAGE-DEPENDENT MOVEMENTS OF ISOLATED OUTER HAIR-CELLS FROM THE ORGAN OF CORTI
    SANTOS-SACCHI, J
    JOURNAL OF NEUROSCIENCE, 1989, 9 (08): : 2954 - 2962
  • [4] Somatic stiffness of cochlear outer hair cells is voltage-dependent
    He, DZZ
    Dallos, P
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 8223 - 8228
  • [5] DIHYDROPYRIDINES AND VERAPAMIL INHIBIT VOLTAGE-DEPENDENT K+ CURRENT IN ISOLATED OUTER HAIR-CELLS OF THE GUINEA-PIG
    LIN, X
    HUME, RI
    NUTTALL, AL
    HEARING RESEARCH, 1995, 88 (1-2) : 36 - 46
  • [6] Properties of Voltage-Dependent Somatic Stiffness of Cochlear Outer Hair Cells
    David Z.Z. He
    Peter Dallos
    Journal of the Association for Research in Otolaryngology, 2000, 1 : 64 - 81
  • [7] Properties of voltage-dependent somatic stiffness of cochlear outer hair cells
    He, DZZ
    Dallos, P
    JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2000, 1 (01): : 64 - 81
  • [8] VOLTAGE-DEPENDENT CHANNELS IN DISSOCIATED OUTER HAIR-CELLS OF THE GUINEA-PIG
    NAKAGAWA, T
    KAKEHATA, S
    AKAIKE, N
    KOMUNE, S
    TAKASAKA, T
    UEMURA, T
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1994, 251 : S57 - S60
  • [9] THE EFFECT OF SALICYLATE ON THE VOLTAGE-DEPENDENT CAPACITANCE OF OUTER HAIR-CELLS ISOLATED FROM THE GUINEA-PIG COCHLEA
    TUNSTALL, MJ
    GALE, JE
    ASHMORE, JF
    JOURNAL OF PHYSIOLOGY-LONDON, 1994, 476P : P75 - P76
  • [10] EVOKED MECHANICAL RESPONSES OF ISOLATED COCHLEAR OUTER HAIR-CELLS
    BROWNELL, WE
    BADER, CR
    BERTRAND, D
    DERIBAUPIERRE, Y
    SCIENCE, 1985, 227 (4683) : 194 - 196
12345