CISPLATIN BLOCKS VOLTAGE-DEPENDENT CALCIUM CURRENT IN DISSOCIATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA

被引：16
|
作者：
YAMAMOTO, T
KAKEHATA, S
SAITO, T
SAITO, H
AKAIKE, N
机构：
[1] FUKUI MED SCH,DEPT OTOLARYNGOL,FUKUI,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT OTOLARYNGOL,SENDAI,JAPAN
来源：
BRAIN RESEARCH | 1994年 / 648卷 / 02期
关键词：
OUTER HAIR CELL; GUINEA PIG; CISPLATIN; OTOTOXICITY; CALCIUM CURRENT; WHOLE-CELL VOLTAGE CLAMP;
D O I：
10.1016/0006-8993(94)91130-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.
引用
收藏
页码：296 / 298
页数：3
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