TRANSPLATIN BLOCKS VOLTAGE-DEPENDENT CALCIUM CURRENT IN ISOLATED COCHLEAR OUTER HAIR-CELLS BUT IS NOT OTOTOXIC IN-VIVO

被引：2
|
作者：
SAITO, T
YAMAMOTO, T
ZHANG, ZJ
YAMADA, T
MANABE, Y
SAITO, H
机构：
[1] Department of Otolaryngology, Fukui Medical School, Yoshida-gun, 910-11 Fukui, Matsuoka-cho
来源：
BRAIN RESEARCH | 1995年 / 697卷 / 1-2期
关键词：
TRANSPLATIN; CISPLATIN; OTOTOXICITY; COCHLEAR OUTER HAIR CELL; WHOLE-CELL PATCH-CLAMP; VOLTAGE-DEPENDENT CALCIUM CHANNEL; COMPOUND ACTION POTENTIAL;
D O I：
10.1016/0006-8993(95)00998-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of cisplatin (cis-DDP) and transplatin (trans-DDP) on the voltage-dependent calcium current (I-Ca) of outer hair cells isolated from the guinea pig cochlea were compared using the whole-cell patch-clamp technique. Both cis-DDP and trans-DDP blocked I-Ca in a concentration-dependent manner. Trans-DDP did not show ototoxicity or nephrotoxicity in vivo. From these results, it was suggested that the effect of cis-DDP on I-Ca does not directly lead to cell death.
引用
收藏
页码：276 / 279
页数：4
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