PHOSPHATE DERIVATIVES OF D4T AS INHIBITORS OF HIV

被引：30

作者：

MCGUIGAN, C

SHEEKA, HM

MAHMOOD, N

HAY, A

机构：

[1] MRC,COLLABORAT CTR,LONDON NW7 1AD,ENGLAND

[2] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80315-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphate derivatives of the anti-HIV nucleoside analogue d4T were prepared as potential pro-drugs of the bio-active free nucleotide. The anti-viral activity of the derivatives varies greatly with the phosphate structure. but several are active below 1 muM. All of the compounds are less toxic than the parent nucleoside analogue; in one case this leads to enhanced antiviral selectivity.

引用

页码：1203 / 1206

页数：4

共 50 条

[1] Phosphoramidate derivatives of d4T as inhibitors of HIV: The effect of amino acid variation
McGuigan, C
Tsang, HW
Cahard, D
Turner, K
Velazquez, S
Salgado, A
Bidois, L
Naesens, L
DeClercq, E
Balzarini, J
[J]. ANTIVIRAL RESEARCH, 1997, 35 (03) : 195 - 204
[2] D4T nucleoside combinations for HIV
Pollard, RB
[J]. ANTIVIRAL RESEARCH, 1996, 29 (01) : 101 - 104
[3] SYNTHESIS AND ANTI-HIV EVALUATION OF D4T AND D4T 5'-MONOPHOSPHATE PRODRUGS
SERGHERAERT, C
PIERLOT, C
TARTAR, A
HENIN, Y
LEMAITRE, M
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (07) : 826 - 830
[4] Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA
Pokrovsky, AG
Pronayeva, TR
Fedyuk, NV
Shirokova, EA
Khandazhinskaya, AL
Tarusova, NB
Karpenko, IL
Krayevsky, AA
[J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2001, 20 (4-7): : 767 - 769
[5] Efficient Synthesis of d4T Diphosphate and d4T Triphosphate
Xie, Zhen-Biao
Gong, Shan-Shan
Sun, Qi
[J]. MATERIALS SCIENCE, ENVIRONMENT PROTECTION AND APPLIED RESEARCH, 2014, 908 : 211 - 214
[6] Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides
Shirokova, EA
Jasko, MV
Khandazhinskaya, AL
Ivanov, AV
Yanvarev, DV
Skoblov, YS
Mitkevich, VA
Bocharov, EV
Pronyaeva, TR
Fedyuk, NV
Kukhanova, MK
Pokrovsky, AG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (14) : 3606 - 3614
[7] SYNTHESIS OF 5-HOMOLOGOUS AZT AND D4T DERIVATIVES
KJAERSGAARD, U
PEDERSEN, EB
NIELSEN, C
ELTORGOMAN, AM
[J]. ACTA CHEMICA SCANDINAVICA, 1992, 46 (10): : 1016 - 1020
[8] SAFETY AND INTERACTION OF DDL AND D4T IN ASYMPTOMATIC HIV PATIENTS
SEIFERT, RD
CUTLER, NR
SRAMEK, JJ
STEWART, M
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 55 (02) : 193 - 193
[9] Adding Saquinavir to d4T in advanced HIV infected patients
Rutschmann, OT
Kaiser, L
Fathi, M
Perrin, L
Hirschel, B
[J]. AIDS, 1996, 10 : P41 - P41
[10] SYNTHESIS AND HIV ACTIVITY OF PHOSPHONATE ISOSTERES OF D4T MONOPHOSPHATE
KIM, CU
BRONSON, JJ
FERRARA, LM
MARTIN, JC
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (05) : 367 - 370

← 1 2 3 4 5 →