Efficient Synthesis of d4T Diphosphate and d4T Triphosphate

被引：0
|
作者：
Xie, Zhen-Biao [1 ]
Gong, Shan-Shan [1 ]
Sun, Qi [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nancfdhang 330013, Jiangxi, Peoples R China
来源：
MATERIALS SCIENCE, ENVIRONMENT PROTECTION AND APPLIED RESEARCH | 2014年 / 908卷
关键词：
d4T; triphosphate; diphosphate; phosphoropiperidate; 4,5-dicyanoimidazole; CELLS;
D O I：
10.4028/www.scientific.net/AMR.908.211
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The diphosphate and triphosphate of an antiviral 2',3'-dideoxynucleoside, d4T, were synthesized via a P(V)-N activation method. The key d4T phosphoropiperidate intermediate was obtained by a redox condensation method based on 2,2'-dithiodipyridine/triphenylphosphine system. The reaction of the phosphoropiperidate with phosphate and pyrophosphate in the presence of acidic 4,5-dicyanoimidazole activator afforded the desired d4T diphosphate and triphosphate in high isolated yields.
引用
收藏
页码：211 / 214
页数：4
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