Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA

被引：19
|
作者：
Pokrovsky, AG [1 ]
Pronayeva, TR
Fedyuk, NV
Shirokova, EA
Khandazhinskaya, AL
Tarusova, NB
Karpenko, IL
Krayevsky, AA
机构：
[1] SRC Virol & Biotechnol Vector, Koltsov 630059, Russia
[2] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期
关键词：
D O I：
10.1081/NCN-100002426
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.
引用
收藏
页码：767 / 769
页数：3
相关论文
共 50 条
  • [1] Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides
    Shirokova, EA
    Jasko, MV
    Khandazhinskaya, AL
    Ivanov, AV
    Yanvarev, DV
    Skoblov, YS
    Mitkevich, VA
    Bocharov, EV
    Pronyaeva, TR
    Fedyuk, NV
    Kukhanova, MK
    Pokrovsky, AG
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (14) : 3606 - 3614
  • [2] Synthesis of AZT/d4T boranophosphates as anti-HIV prodrug candidates
    Lin, CX
    Fu, H
    Tu, GZ
    Zhao, YF
    [J]. SYNTHESIS-STUTTGART, 2004, (04): : 509 - 516
  • [3] New and efficient approach to aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
    Li, XS
    Fu, H
    Jiang, YY
    Zhao, YF
    Liu, JY
    [J]. SYNLETT, 2004, (14) : 2600 - 2602
  • [4] Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity
    Taourirte, M
    Mohamed, LA
    Rochdi, A
    Vasseur, JJ
    Fernández, S
    Ferrero, M
    Gotor, V
    Pannecouque, C
    De Clercq, E
    Lazrek, HB
    [J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (04): : 701 - 714
  • [5] A NOVEL ROUTE TO THE ANTI-HIV NUCLEOSIDE D4T
    LIPSHUTZ, BH
    STEVENS, KL
    LOWE, RF
    [J]. TETRAHEDRON LETTERS, 1995, 36 (16) : 2711 - 2712
  • [6] One-pot synthesis of aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
    Jiang, P
    Guo, J
    Fu, H
    Jiang, YY
    Zhao, YF
    [J]. SYNLETT, 2005, (16) : 2537 - 2539
  • [7] Phosphorylation of anti-HIV nucleotides AZT, d4T and ddNTP by nucleoside diphosphate kinase
    Deville-Bonne, D
    Schneider, B
    Meyer, P
    Sarfati, R
    Canard, B
    Janin, J
    Véron, M
    [J]. ANTIVIRAL RESEARCH, 2000, 46 (01) : A42 - A42
  • [8] One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT
    Sun, XB
    Kang, JX
    Zhao, YF
    [J]. CHEMICAL COMMUNICATIONS, 2002, (20) : 2414 - 2415
  • [9] SYNTHESIS AND ANTI-HIV EVALUATION OF D4T AND D4T 5'-MONOPHOSPHATE PRODRUGS
    SERGHERAERT, C
    PIERLOT, C
    TARTAR, A
    HENIN, Y
    LEMAITRE, M
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (07) : 826 - 830
  • [10] Anti-HIV therapy with AZT prodrugs: AZT phosphonate derivatives, current state and prospects
    Khandazhinskaya, Anastasiya
    Matyugina, Elena
    Shirokova, Elena
    [J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2010, 6 (06) : 701 - 714
12345