SYNTHESIS OF NATURALLY-OCCURRING LD-HEPP CONTAINING DISACCHARIDES

被引：11
|
作者：
BOONS, GJPH
STEYGER, R
OVERHAND, M
VANDERMAREL, GA
VANBOOM, JH
机构：
[1] Gorlaeus Laboratories, 2300, RA Leiden
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 1991年 / 10卷 / 06期
关键词：
D O I：
10.1080/07328309108543968
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diastereoselective hydroxymethylation of a suitably protected a-D-manno-hexodialdo-1,5-pyranoside with the Grignard reagent derived from (phenyldimethylsilyl)methyl chloride gives, after additional protecting group manipulations, an easy access to one donor and two acceptors of LD-Hepp. The latter derivatives could be applied successfully for the preparation of the disaccharides alpha-D-GlcpN-(1-7)-L-alpha-D-Hepp-OMe and L-alpha-D-Hepp-(1-6)-L-alpha-D-Hepp-OMe.
引用
收藏
页码：995 / 1007
页数：13
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