SYNTHESIS OF NATURALLY-OCCURRING LD-HEPP CONTAINING DISACCHARIDES

Diastereoselective hydroxymethylation of a suitably protected a-D-manno-hexodialdo-1,5-pyranoside with the Grignard reagent derived from (phenyldimethylsilyl)methyl chloride gives, after additional protecting group manipulations, an easy access to one donor and two acceptors of LD-Hepp. The latter derivatives could be applied successfully for the preparation of the disaccharides alpha-D-GlcpN-(1-7)-L-alpha-D-Hepp-OMe and L-alpha-D-Hepp-(1-6)-L-alpha-D-Hepp-OMe.