SIMIAN IMMUNODEFICIENCY VIRUS VECTORS - REPLICATION AND PSEUDOTYPING

被引：0
|
作者：
RIZVI, TA
PANGANIBAN, AT
机构：
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 1992年 / 21卷 / 2-3期
关键词：
RETROVIRUS; ENVELOPE GLYCOPROTEIN; RNA PACKAGING; HYG(R)GENE;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. it was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus. Moreover, SIV RNA was packaged and propagated by core particles of the heterologous lentivirus, HIV-1. These results indicate that coinfection of cells with SIV and other retroviruses could lead to infection of new cell types in nature.
引用
收藏
页码：69 / 73
页数：5
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