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SIMIAN IMMUNODEFICIENCY VIRUS VECTORS - REPLICATION AND PSEUDOTYPING
被引:0
|作者:
RIZVI, TA
PANGANIBAN, AT
机构:
关键词:
RETROVIRUS;
ENVELOPE GLYCOPROTEIN;
RNA PACKAGING;
HYG(R)GENE;
D O I:
暂无
中图分类号:
S85 [动物医学(兽医学)];
学科分类号:
0906 ;
摘要:
We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. it was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus. Moreover, SIV RNA was packaged and propagated by core particles of the heterologous lentivirus, HIV-1. These results indicate that coinfection of cells with SIV and other retroviruses could lead to infection of new cell types in nature.
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页码:69 / 73
页数:5
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