MARKED REDUCTION OF RADIATION-INDUCED MICRONUCLEI IN HUMAN BLOOD-LYMPHOCYTES PRETREATED WITH MELATONIN

被引：75
|
作者：
VIJAYALAXMI [1 ]
REITER, RJ [1 ]
SEWERYNEK, E [1 ]
POEGGELER, B [1 ]
LEAL, BZ [1 ]
MELTZ, ML [1 ]
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284
来源：
RADIATION RESEARCH | 1995年 / 143卷 / 01期
关键词：
D O I：
10.2307/3578932
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human peripheral blood lymphocytes which were pretreated in vitro with melatonin, an endogenously synthesized pineal hormone, for 20 min at 37 +/- 1 degrees C exhibited a significant and concentration-dependent reduction in the frequency of gamma-radiation-induced micronuclei compared with irradiated cells which did not receive the pretreatment. The extent of the reduction observed with 2.0 mM melatonin was similar to that found in lymphocytes pretreated for 20 min with 1.0 M dimethylsulfoxide, a known free radical scavenger, These observations indicate that melatonin may have an active role in protection of humans against genetic damage due to endogenously produced free radicals, and also may be of use in reducing damage due to exposure to physical and chemical mutagens and carcinogens which generate free radicals. (C) 1995 by Radiation Research Society
引用
收藏
页码：102 / 106
页数：5
相关论文
共 50 条
  • [1] MELATONIN PROTECTS HUMAN BLOOD-LYMPHOCYTES FROM RADIATION-INDUCED CHROMOSOME-DAMAGE
    VIJAYALAXMI
    REITER, RJ
    MELTZ, ML
    [J]. MUTATION RESEARCH LETTERS, 1995, 346 (01): : 23 - 31
  • [2] Effect of blood storage on radiation-induced micronuclei in human lymphocytes
    Lee, TK
    O'Brien, K
    Eaves, GS
    Christie, KI
    Varga, L
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1999, 444 (01) : 201 - 206
  • [3] RADIATION-INDUCED MICRONUCLEI IN SUBPOPULATIONS OF HUMAN-LYMPHOCYTES
    WUTTKE, K
    STREFFER, C
    MULLER, WU
    [J]. MUTATION RESEARCH, 1993, 286 (02): : 181 - 188
  • [4] Mistletoe lectins and radiation-induced micronuclei in human lymphocytes
    Köteles, GJ
    Kubasova, T
    Horváth, G
    Pfüller, U
    [J]. EFFECTS OF ANTINUTRIENTS ON THE NUTRITIONAL VALUE OF LEGUME DIETS, VOL 6, 1999, : 134 - 138
  • [5] Protective effects of cimetidine on radiation-induced micronuclei and apoptosis in human peripheral blood lymphocytes
    Kojima, Y
    Kondo, T
    Zhao, QL
    Shoji, M
    Futatsuya, R
    [J]. FREE RADICAL RESEARCH, 2002, 36 (03) : 255 - 263
  • [6] THE YIELD OF MICRONUCLEI IN HUMAN BLOOD-LYMPHOCYTES TREATED WITH RADIOACTIVE CESIUM
    BALASEM, AN
    ALI, ASK
    ABDULKHALIQ, JJ
    [J]. RADIATION PROTECTION DOSIMETRY, 1993, 46 (04) : 295 - 297
  • [7] Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes
    Vijayalaxmi
    Reiter, RJ
    Herman, TS
    Meltz, ML
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 397 (02) : 203 - 208
  • [8] Mangiferin, a glucosylxanthone, protects against the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes
    Jagetia, GC
    Venkatesha, VA
    [J]. HIGH LEVELS OF NATURAL RADIATION AND RADON AREAS: RADIATION DOSE AND HEALTH EFFECTS, 2005, 1276 : 195 - 196
  • [9] DOSE DEPENDENCE OF RADIATION-INDUCED MICRONUCLEI IN CYTOKINESIS-BLOCKED HUMAN-LYMPHOCYTES
    SILVA, MJ
    CAROTHERS, A
    DIAS, A
    LUIS, JH
    PIPER, J
    BOAVIDA, MG
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY, 1994, 322 (02): : 117 - 128
  • [10] Antioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-Radiation
    Jagetia, Ganesh Chandra
    [J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2021, 97 (04) : 485 - 493
12345