MARKED REDUCTION OF RADIATION-INDUCED MICRONUCLEI IN HUMAN BLOOD-LYMPHOCYTES PRETREATED WITH MELATONIN

被引：75
|
作者：
VIJAYALAXMI [1 ]
REITER, RJ [1 ]
SEWERYNEK, E [1 ]
POEGGELER, B [1 ]
LEAL, BZ [1 ]
MELTZ, ML [1 ]
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284
来源：
RADIATION RESEARCH | 1995年 / 143卷 / 01期
关键词：
D O I：
10.2307/3578932
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human peripheral blood lymphocytes which were pretreated in vitro with melatonin, an endogenously synthesized pineal hormone, for 20 min at 37 +/- 1 degrees C exhibited a significant and concentration-dependent reduction in the frequency of gamma-radiation-induced micronuclei compared with irradiated cells which did not receive the pretreatment. The extent of the reduction observed with 2.0 mM melatonin was similar to that found in lymphocytes pretreated for 20 min with 1.0 M dimethylsulfoxide, a known free radical scavenger, These observations indicate that melatonin may have an active role in protection of humans against genetic damage due to endogenously produced free radicals, and also may be of use in reducing damage due to exposure to physical and chemical mutagens and carcinogens which generate free radicals. (C) 1995 by Radiation Research Society
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页码：102 / 106
页数：5
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