AUGMENTED EXPRESSION OF HSP72 PROTEIN IN NORMAL HUMAN FIBROBLASTS IRRADIATED WITH ULTRAVIOLET-LIGHT

被引：35

作者：

SUZUKI, K ^{[1
]}

WATANABE, M ^{[1
]}

机构：

[1] NAGASAKI UNIV,FAC PHARMACEUT SCI,DEPT HLTH SCI,DIV RADIAT,NAGASAKI 852,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)81541-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normal human fibroblasts synthesized heat shock protein (HSP) 72 constitutively and its expression was augmented 6 hours after UV irradiation. Maximum induction of HSP72 was obtained at 12 hours and HSP72 showed a punctuated distribution in nucleus. While unscheduled DNA synthesis was almost completed 12 hours after UV irradiation, the S phase fraction decreased immediately and recovered after 6 hours. Thus, HSP72 augmentation was occurred coincidentally with the recovery of S phase, and suggested that HSP72 had some function during the recovery of DNA replication inhibited after UV irradiation. © 1992 Academic Press, Inc.

引用

页码：1257 / 1264

页数：8

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