AUGMENTED EXPRESSION OF HSP72 PROTEIN IN NORMAL HUMAN FIBROBLASTS IRRADIATED WITH ULTRAVIOLET-LIGHT

被引：35
|
作者：
SUZUKI, K [1 ]
WATANABE, M [1 ]
机构：
[1] NAGASAKI UNIV,FAC PHARMACEUT SCI,DEPT HLTH SCI,DIV RADIAT,NAGASAKI 852,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(05)81541-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Normal human fibroblasts synthesized heat shock protein (HSP) 72 constitutively and its expression was augmented 6 hours after UV irradiation. Maximum induction of HSP72 was obtained at 12 hours and HSP72 showed a punctuated distribution in nucleus. While unscheduled DNA synthesis was almost completed 12 hours after UV irradiation, the S phase fraction decreased immediately and recovered after 6 hours. Thus, HSP72 augmentation was occurred coincidentally with the recovery of S phase, and suggested that HSP72 had some function during the recovery of DNA replication inhibited after UV irradiation. © 1992 Academic Press, Inc.
引用
收藏
页码：1257 / 1264
页数：8
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