SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NOVEL BENZIMIDAZOLE DERIVATIVES

Benzimidazole is a heterocyclic aromatic organic compound. Benzimidazole derivatives are of wide interest because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favorable selectivity ratio. Looking at the importance of benzimidazole and oxadiazole nucleus, it was thought that it would be worthwhile to design and synthesize new benzimidazole derivatives. In recent years, attention has increasingly been given to the synthesis of benzimidazole derivatives. Hence, there will always be a vital need to discover new chemotherapeutic agents to overcome the emergence of resistance and ideally shorten the duration of therapy. Due to the structural similarity to purine, antibacterial ability of benzimidazoles is explained by their competition with purines resulting in inhibition of the synthesis of bacterial nucleic acids and proteins. Thus, from the present study it can be concluded that cyclohexyl derivatives of benzimidazole ring have significant antibacterial activity.