SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 4-CARBAMOYL-6-BETA-THIENYL-4,5-DIHYDROPYRIDAZIN-3-(2H)ONES

被引：0

作者：

PINNA, GA

CURZU, MM

GAVINI, E

MULE, A

PIRISINO, G

SATTA, M

PEANA, A

机构：

[1] UNIV SASSARI,CATTEDRA FARMACOGNOSIA,VIA MURONI 23,I-07100 SASSARI,ITALY

[2] UNIV SASSARI,IST CHIM FARMACEUT,I-07100 SASSARI,ITALY

[3] UNIV SASSARI,IST TECN FARMACEUT,I-07100 SASSARI,ITALY

来源：

FARMACO | 1993年 / 48卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test.

引用

页码：1239 / 1248

页数：10

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