SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 4-CARBAMOYL-6-BETA-THIENYL-4,5-DIHYDROPYRIDAZIN-3-(2H)ONES

被引：0
|
作者：
PINNA, GA
CURZU, MM
GAVINI, E
MULE, A
PIRISINO, G
SATTA, M
PEANA, A
机构：
[1] UNIV SASSARI,CATTEDRA FARMACOGNOSIA,VIA MURONI 23,I-07100 SASSARI,ITALY
[2] UNIV SASSARI,IST CHIM FARMACEUT,I-07100 SASSARI,ITALY
[3] UNIV SASSARI,IST TECN FARMACEUT,I-07100 SASSARI,ITALY
来源：
FARMACO | 1993年 / 48卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test.
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页码：1239 / 1248
页数：10
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