BOMBESIN STIMULATES C-FOS AND C-JUN MESSENGER-RNAS IN SMALL-CELL LUNG-CANCER CELLS

被引：42

作者：

DRAOUI, M

CHUNG, P

PARK, M

BIRRER, M

JAKOWLEW, S

MOODY, TW

机构：

[1] NCI,DCPC,BIOMARKERS & PREVENT RES BRANCH,ROCKVILLE,MD 20850

[2] GEORGE WASHINGTON UNIV,MED CTR,DEPT MOLEC BIOL & BIOCHEM,WASHINGTON,DC 20037

来源：

PEPTIDES | 1995年 / 16卷 / 02期

关键词：

SMALL CELL LUNG CANCER (SCLC); GRP RECEPTOR; C-FOS; C-JUN;

D O I：

10.1016/0196-9781(94)00173-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of bombesin/gastrin-releasing peptide (BN/GRP) on c-fos and c-jun gene expression were investigated using small cell lung cancer (SCLC) cells. BN(10 nM) increased c-fos mRNA fivefold using NCI-H345 or NCI-HS 10 cells. The increase was concentration dependent with 1 nM BN half-maximally increasing c-fos mRNA. Also, the increase in c-fos mRNA caused by BN was time dependent, being maximal after 1 h and returning to basal values after 4 h. GRP and GRP(14-27) but not GRP(1-16) increased c-fos mRNA. BW2258U89 (1 mu M), a GRP receptor antagonist, had no effect on basal c-fos but inhibited the increase in c-fos mRNA caused by 10 nM BN. Also, BN transiently increased c-jun mRNA twofold and the increase caused by BN was blocked by BW2258U89. These data suggest that GRP receptors may regulate nuclear oncogene gene expression in SCLC cells.

引用

页码：289 / 292

页数：4

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