Cucurbitane triterpenoids from Hemsleya penxianensis

被引：0

作者：

Chen, Jian-Chao ^{[1
]}

Zhou, Lin ^{[1
]}

Wang, Yun-Hua ^{[2
]}

Tian, Ren-Rong ^{[2
]}

Yan, Yun-Xin ^{[1
]}

Nian, Yin ^{[1
]}

Sun, Yun ^{[1
]}

Zheng, Yong-Tang ^{[2
]}

Qiu, Ming-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China

来源：

NATURAL PRODUCTS AND BIOPROSPECTING | 2012年 / 2卷 / 04期

关键词：

cucurbitane triterpenoid; jinfushanencin; jinfushanoside; Hemsleya penxianensis;

D O I：

10.1007/s13659-011-0044-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cucurbitacins, jinfushanencins A (1) and B (2), seven new cucurbitane glycosides, jinfushanosides E-K (3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell (EC50 = 5.9 mu g/mL) with a selectivity index of 13.5.

引用

页码：138 / 144

页数：7

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