Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia

被引：38

作者：

Zhao, Gao-Ting ^{[1
]}

Liu, Jie-Qing ^{[2
]}

Deng, Yuan-Yuan ^{[2
,3
]}

Li, Hai-Zhou ^{[1
]}

Chen, Jian-Chao ^{[2
]}

Zhang, Zhi-Run ^{[2
]}

Zhou, Lin ^{[2
]}

Qiu, Ming-Hua ^{[2
,3
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FITOTERAPIA | 2014年 / 95卷

关键词：

Momordica charantia; Cucurbitaceae; Cucurbitane-type triterpenoids; Cytotoxicity; ABSOLUTE-CONFIGURATION; PROSTATE-CANCER; MO-2(OAC)(4); ASSIGNMENT; COMPLEXES; 1,2-DIOLS; FRUIT;

D O I：

10.1016/j.fitote.2014.03.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5 beta,19-epoxy-25-methoxycucurbita-6,23-diene-3 beta,19-diol (7), 5 beta,19-epoxycucurbita-6, 23-diene-3 beta,19,25-triol (8), kuguacin R (9), and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3 beta-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 143-20.5 mol/L. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：75 / 82

页数：8

共 50 条

[1] Cucurbitane-type triterpenoids from the stems of Momordica charantia
Chang, Chi-I
Chen, Chiy-Rong
Liao, Yun-Wen
Cheng, Hsueh-Ling
Chen, Yo-Chia
Chou, Chang-Hung
[J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (08): : 1327 - 1330
[2] Cucurbitane-type triterpenoids from the leaves of Momordica charantia
Zhang, Yu-Bo
Liu, Huan
Zhu, Cun-Ya
Zhang, Mao-Xin
Li, Yao-Lan
Ling, Bing
Wang, Guo-Cai
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (04) : 358 - 363
[3] Cucurbitane-type triterpenoids from Momordica charantia
Chang, Chi-I
Chen, Chiy-Rong
Liao, Yun-Wen
Cheng, Hsueh-Ling
Chen, Yo-Chia
Chou, Chang-Hung
[J]. JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08): : 1168 - 1171
[4] Cucurbitane-Type Triterpenoids from Momordica charantia
Cheng, Bao-Hui
Chen, Jian-Chao
Liu, Jie-Qing
Zhou, Lin
Qiu, Ming-Hua
[J]. HELVETICA CHIMICA ACTA, 2013, 96 (06) : 1111 - 1120
[5] Cucurbitane-Type Triterpenoids from Momordica charantia
Chen, Chiy-Rong
Liao, Yun-Wen
Kuo, Yueh-Hsiung
Hsu, Jue-Liang
Chang, Chi-I
[J]. NATURAL PRODUCT COMMUNICATIONS, 2017, 12 (06) : 889 - 892
[6] Cucurbitane-Type Triterpenoids from Momordica charantia
Ma, Jun
Whittaker, Paul
Keller, Amy C.
Mazzola, Eugene P.
Pawar, Rahul S.
White, Kevin D.
Callahan, John H.
Kennelly, Edward J.
Krynitsky, Alexander J.
Rader, Jeanne I.
[J]. PLANTA MEDICA, 2010, 76 (15) : 1758 - 1761
[7] Cucurbitane-type triterpenoids from the fruit of Momordica charantia
Kimura, Y
Akihisa, T
Yuasa, N
Ukiya, M
Suzuki, T
Toriyama, M
Motohashi, S
Tokuda, H
[J]. JOURNAL OF NATURAL PRODUCTS, 2005, 68 (05): : 807 - 809
[8] Cucurbitane-Type Triterpenoids from the Fruit Pulp of Momordica charantia
Liao, Yun-Wen
Chen, Chiy-Rong
Kuo, Yueh-Hsiung
Hsu, Jue-Liang
Shih, Wen-Ling
Cheng, Hsueh-Ling
Huang, Tzou-Chi
Chang, Chi-I
[J]. NATURAL PRODUCT COMMUNICATIONS, 2012, 7 (12) : 1575 - 1578
[9] Cucurbitane-type triterpenoids in Momordica charantia Linn.
Lee, Sook Young
Eom, Seok Hyun
Kim, Yong Kyoung
Park, Nam Il
Park, Sang Un
[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2009, 3 (13): : 1264 - 1269
[10] Cucurbitane-type triterpenoids from the aerial parts of Momordica charantia L.
Jiang, Ying
Peng, Xing-Rong
Yu, Mu-Yuan
Wan, Luo-Sheng
Zhu, Guo-Lei
Zhao, Gao-Ting
Zhou, Lin
Qiu, Ming-Hua
Liu, Jian
[J]. PHYTOCHEMISTRY LETTERS, 2016, 16 : 164 - 168

← 1 2 3 4 5 →