Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia

被引：38
|
作者：
Zhao, Gao-Ting [1 ]
Liu, Jie-Qing [2 ]
Deng, Yuan-Yuan [2 ,3 ]
Li, Hai-Zhou [1 ]
Chen, Jian-Chao [2 ]
Zhang, Zhi-Run [2 ]
Zhou, Lin [2 ]
Qiu, Ming-Hua [2 ,3 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
FITOTERAPIA | 2014年 / 95卷
关键词：
Momordica charantia; Cucurbitaceae; Cucurbitane-type triterpenoids; Cytotoxicity; ABSOLUTE-CONFIGURATION; PROSTATE-CANCER; MO-2(OAC)(4); ASSIGNMENT; COMPLEXES; 1,2-DIOLS; FRUIT;
D O I：
10.1016/j.fitote.2014.03.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5 beta,19-epoxy-25-methoxycucurbita-6,23-diene-3 beta,19-diol (7), 5 beta,19-epoxycucurbita-6, 23-diene-3 beta,19,25-triol (8), kuguacin R (9), and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3 beta-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 143-20.5 mol/L. (C) 2014 Elsevier B.V. All rights reserved.
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页码：75 / 82
页数：8
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