DOPAMINERGIC REGULATION OF DOPAMINE RELEASE FROM PC12 CELLS VIA A PERTUSSIS TOXIN-SENSITIVE G-PROTEIN

被引：24

作者：

COURTNEY, ND ^{[1
]}

HOWLETT, AC ^{[1
]}

WESTFALL, TC ^{[1
]}

机构：

[1] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL,1402 S GRAND BLVD,ST LOUIS,MO 63104

来源：

NEUROSCIENCE LETTERS | 1991年 / 122卷 / 02期

关键词：

DOPAMINE; D2; RECEPTOR; PC12; CELL; PERTUSSIS TOXIN; G-PROTEIN; QUINPIROLE;

D O I：

10.1016/0304-3940(91)90873-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regulation of dopamine (DA) release from PC12 cells was investigated. Apomorphine and quinpirole, a selective D2 agonist, significantly reduced K+-evoked DA release, and this reduction was reversed by haloperidol. Furthermore, spiroperidol, a selective D2 antagonist, and haloperidol, a nonselective DA antagonist, enhanced the K+-evoked DA release. Pertussis toxin treatment of the cells abolished the quinpirole-induced reduction of K+-evoked DA release. Also, the haloperidol-induced enhancement of K+-evoked DA release was not seen in pertussis toxin treated cells. These results, therefore, suggest the presence of D2 receptors on PC12 cells which result in the modulation of K+-evoked DA release via a pertussis toxin-sensitive G protein.

引用

页码：261 / 264

页数：4

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