DOPAMINERGIC REGULATION OF DOPAMINE RELEASE FROM PC12 CELLS VIA A PERTUSSIS TOXIN-SENSITIVE G-PROTEIN

被引：24
|
作者：
COURTNEY, ND [1 ]
HOWLETT, AC [1 ]
WESTFALL, TC [1 ]
机构：
[1] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL,1402 S GRAND BLVD,ST LOUIS,MO 63104
来源：
NEUROSCIENCE LETTERS | 1991年 / 122卷 / 02期
关键词：
DOPAMINE; D2; RECEPTOR; PC12; CELL; PERTUSSIS TOXIN; G-PROTEIN; QUINPIROLE;
D O I：
10.1016/0304-3940(91)90873-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Regulation of dopamine (DA) release from PC12 cells was investigated. Apomorphine and quinpirole, a selective D2 agonist, significantly reduced K+-evoked DA release, and this reduction was reversed by haloperidol. Furthermore, spiroperidol, a selective D2 antagonist, and haloperidol, a nonselective DA antagonist, enhanced the K+-evoked DA release. Pertussis toxin treatment of the cells abolished the quinpirole-induced reduction of K+-evoked DA release. Also, the haloperidol-induced enhancement of K+-evoked DA release was not seen in pertussis toxin treated cells. These results, therefore, suggest the presence of D2 receptors on PC12 cells which result in the modulation of K+-evoked DA release via a pertussis toxin-sensitive G protein.
引用
收藏
页码：261 / 264
页数：4
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