CYCLIC ARYL HYDROXAMIC ACIDS - SYNTHESIS AND INHIBITION OF 5-LIPOXYGENASE

被引：10

作者：

MISRA, RN

BOTTI, CM

HASLANGER, MF

ENGEBRECHT, JR

MAHONEY, EM

CIOSEK, CP

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80811-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclic aryl hydroxamic acids 11 were prepared and found to be significantly less potent in inhibiting 5-lipoxygenase than their acyclic analogs 8. This finding provides support to the hypothesis that hydroxamic acids may be inhibiting 5-LO by a mechanism other than simple iron (III) binding.

引用

页码：295 / 298

页数：4

共 50 条

[41] HYDROXAMIC ACID INHIBITORS OF 5-LIPOXYGENASE - QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS
SUMMERS, JB
KIM, KH
MAZDIYASNI, H
HOLMS, JH
RATAJCZYK, JD
STEWART, AO
DYER, RD
CARTER, GW
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (03) : 992 - 998
[42] UTILIZATION OF ALTERNATIVE FATTY-ACIDS BY THE 5-LIPOXYGENASE
LEWIS, RA
LEE, TH
AUSTEN, KF
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 189 (APR-): : 32 - AGFD
[43] The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein
Randy L. Bell
Richard R. Harris
Clinical Reviews in Allergy & Immunology, 1999, 17 : 91 - 109
[44] EXPRESSION OF 5-LIPOXYGENASE AND 5-LIPOXYGENASE ACTIVATION PROTEIN IN GLOMERULONEPHRITIS
RIFAI, A
SAKAI, H
YAGAME, M
KIDNEY INTERNATIONAL, 1993, 43 : S95 - S99
[45] Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils
Flamand, N
Surette, ME
Picard, S
Bourgoin, S
Borgeat, P
MOLECULAR PHARMACOLOGY, 2002, 62 (02) : 250 - 256
[46] The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein
Bell, RL
Harris, RR
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 1999, 17 (1-2) : 91 - 109
[47] SELECTIVE 5-LIPOXYGENASE INHIBITION IN ULCERATIVE-COLITIS
LAURSEN, LS
NAESDAL, J
BUKHAVE, K
LAURITSEN, K
RASKMADSEN, J
LANCET, 1990, 335 (8691): : 683 - 685
[48] INHIBITION OF ALVEOLAR MACROPHAGE 5-LIPOXYGENASE METABOLISM BY AURANOFIN
PETERSGOLDEN, M
SHELLY, C
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (10) : 1589 - 1595
[49] In vitro inhibition of 5-lipoxygenase by natural quinone compounds
Landa, P.
Kutil, Z.
Malik, J.
Kokoska, L.
Widowitz, U.
Marsik, P.
Bauer, R.
Vanek, T.
PLANTA MEDICA, 2011, 77 (12) : 1425 - 1425
[50] INHIBITION OF ARACHIDONATE 5-LIPOXYGENASE BY PHENOLIC-COMPOUNDS
IWAKAMI, S
SHIBUYA, M
TSENG, CF
HANAOKA, F
SANKAWA, U
CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (09) : 3960 - 3963

← 1 2 3 4 5 →