CYCLIC ARYL HYDROXAMIC ACIDS - SYNTHESIS AND INHIBITION OF 5-LIPOXYGENASE

被引：10

作者：

MISRA, RN

BOTTI, CM

HASLANGER, MF

ENGEBRECHT, JR

MAHONEY, EM

CIOSEK, CP

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80811-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclic aryl hydroxamic acids 11 were prepared and found to be significantly less potent in inhibiting 5-lipoxygenase than their acyclic analogs 8. This finding provides support to the hypothesis that hydroxamic acids may be inhibiting 5-LO by a mechanism other than simple iron (III) binding.

引用

页码：295 / 298

页数：4

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