ENTEROBACTERIACAE, PRODUCING ESBLS AND METALLO-beta-LACTAMASE NDM-1, ISOLATED IN HOSPITALS OF BALTIC REGION COUNTRIES

被引:0
|
作者
Egorova, S. A. [1 ]
Kaftyreva, L. A. [1 ]
Lipskaya, L., V [2 ]
Konovalenko, I. B. [3 ]
Pyasetskaya, M. F.
Kurchikova, T. S. [4 ]
Vedernikova, N. B. [5 ]
Morozova, O. T. [6 ]
Smirnova, M., V [7 ]
Popenko, L. N. [8 ]
Lubushkina, M., I
Savochkina, J. A.
Makarova, M. A. [1 ]
Suzhaeva, L., V [1 ]
Ostankova, J., V [1 ,9 ]
Ivanova, M. N.
Pavelkovich, A. M.
Naaber, P. [10 ,11 ]
Sepp, E. [11 ]
Koljalg, S. [11 ]
Miciuleviciene, J. [12 ]
Balode, A. [13 ]
机构
[1] FBUN Res Inst Epidemiol & Microbiol, St Petersburg, Russia
[2] City Clin Hosp 40, St Petersburg, Russia
[3] City Clin Hosp 31, St Petersburg, Russia
[4] City Childrens Hosp 17, St Petersburg, Russia
[5] St George Great Martyr Hosp, St Petersburg, Russia
[6] City Childrens Hosp 1, St Petersburg, Russia
[7] City Mariinsky Hosp, St Petersburg, Russia
[8] Inst Emergency Care, St Petersburg, Russia
[9] FBUN Central Res Inst Epidemiol, Moscow, Russia
[10] Eastern Central Hosp, Tallinn, Estonia
[11] Univ Tartu, Tartu, Estonia
[12] Vilnius City Clinic Hosp, Vilnius, Lithuania
[13] Univ Clin Hosp, Riga, Latvia
来源
INFEKTSIYA I IMMUNITET | 2013年 / 3卷 / 01期
关键词
K; pneumoniae; E; coli; resistance; CTX-M; NDM-1;
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012. Prevalence of cephalosporin resistant isolates varied in different hospitals: E. coli - from 7,8 to 50%, K. pneumoniae -from 25,4 to 88,4%. Isolates produced extended spectrum beta-lactamases CTX-M, mainly CTX-M-1, also CTX-M-2 and CTX-M-9. Twenty two carbapenem-resistant K. pneumoniae strains (also resistant to other antimicrobials) were isolated in three hospitals. MALDI-TOF MS showed that carbapenem resistance was caused by carbapenemase. Carbapenemases of all isolates belonged to metallo-beta-lactamases according to results of the ROSCO Diagnostica tests. The gene coding production of New Delhi metallo-beta-lactamase (blaNDM-1) were detected in all strains. Our data confirmed that the main cephalosporin resistance mechanism of E. coli. K. pneumoniae in Baltic region (including Russia, St-Petersburg) is CTX-M-1 production. For the first time in Russia K. pneumoniae strains producing metallo-beta-lactamases NDM-1 were isolated in several hospitals of St-Petersburg.
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页码:29 / 36
页数:8
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