CHRONOBIOLOGY - IMPLICATIONS FOR CANCER-CHEMOTHERAPY

被引：8
|
作者：
BJARNASON, GA
机构：
[1] Division of Medical Oncology, Toronto-Bayview Regional Cancer Center, Toronto, ON
来源：
ACTA ONCOLOGICA | 1995年 / 34卷 / 05期
关键词：
D O I：
10.3109/02841869509094037
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Experimental studies have documented that both the toxicity and the antitumor activity of many cancer drugs are time dependent. Early clinical trials have confirmed this observation for several drugs. The basic concepts of chronobiology and its application to pharmacology are reviewed. As an example, clinical trials of circadian fluoropyrimidine delivery are reviewed. Other clinical results are presented in table form. The mechanisms pertinent to the circadian time dependence of fluoropyrimidines are discussed.
引用
收藏
页码：615 / 624
页数：10
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