CHRONOBIOLOGY - IMPLICATIONS FOR CANCER-CHEMOTHERAPY

被引：8
|
作者：
BJARNASON, GA
机构：
[1] Division of Medical Oncology, Toronto-Bayview Regional Cancer Center, Toronto, ON
来源：
ACTA ONCOLOGICA | 1995年 / 34卷 / 05期
关键词：
D O I：
10.3109/02841869509094037
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Experimental studies have documented that both the toxicity and the antitumor activity of many cancer drugs are time dependent. Early clinical trials have confirmed this observation for several drugs. The basic concepts of chronobiology and its application to pharmacology are reviewed. As an example, clinical trials of circadian fluoropyrimidine delivery are reviewed. Other clinical results are presented in table form. The mechanisms pertinent to the circadian time dependence of fluoropyrimidines are discussed.
引用
收藏
页码：615 / 624
页数：10
相关论文
共 50 条
  • [31] APOPTOSIS AND CANCER-CHEMOTHERAPY
    HICKMAN, JA
    POTTEN, CS
    MERRITT, AJ
    FISHER, TC
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1994, 345 (1313) : 319 - 325
  • [32] CANCER-CHEMOTHERAPY IN THE ELDERLY
    BALDUCCI, L
    PHILLIPS, DM
    WALLACE, C
    HARDY, C
    AMERICAN FAMILY PHYSICIAN, 1987, 35 (03) : 133 - 143
  • [33] LIPOSOME CIRCULATION TIME AND TUMOR TARGETING - IMPLICATIONS FOR CANCER-CHEMOTHERAPY
    GABIZON, AA
    ADVANCED DRUG DELIVERY REVIEWS, 1995, 16 (2-3) : 285 - 294
  • [34] PHARMACOKINETICS AND CANCER-CHEMOTHERAPY
    WORKMAN, P
    GRAHAM, MA
    CANCER SURVEYS, 1993, 17 : R7 - R8
  • [35] CANCER-CHEMOTHERAPY AND PHARMACOLOGY
    EGORIN, MJ
    NEWELL, H
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 34 (01) : 1 - 1
  • [36] IMPROVED CANCER-CHEMOTHERAPY
    LOKICH, JJ
    POSTGRADUATE MEDICINE, 1990, 87 (02) : 239 - &
  • [37] PANCREATITIS AND CANCER-CHEMOTHERAPY
    PUCKETT, JB
    BUTLER, WM
    MCFARLAND, JA
    ANNALS OF INTERNAL MEDICINE, 1982, 97 (03) : 453 - 453
  • [38] REGIONAL CANCER-CHEMOTHERAPY
    ENSMINGER, WD
    GYVES, JW
    CANCER TREATMENT REPORTS, 1984, 68 (01): : 101 - 115
  • [39] CANCER-CHEMOTHERAPY AND THROMBOSIS
    LEVINE, M
    ARNOLD, A
    KELLEHER, L
    LORD, S
    HRYNIUK, W
    HIRSH, J
    GENT, M
    BREAST CANCER RESEARCH AND TREATMENT, 1987, 10 (01) : 122 - 122
  • [40] CANNABIS AND CANCER-CHEMOTHERAPY
    COLLS, BM
    LANCET, 1980, 1 (8179): : 1187 - 1188
12345