ESTIMATION OF XIPAMIDE BY USING HPLC IN PURE AND PHARMACEUTICAL DOSAGE FORM

被引：1

作者：

Rajendran, Rameshpetchi ^{[1
]}

Devikasubramaniyan ^{[1
]}

Sura, Ramya Sri ^{[2
]}

Kumar, A. Arun ^{[1
]}

Mounika, A. ^{[1
]}

Sowjanya, A. ^{[1
]}

Priyanka, B. ^{[1
]}

机构：

[1] Bomma Inst Pharm, Khammam 507318, Telangana, India

[2] Osmania Univ, Univ Technol, Hyderabad 500007, Telangana, India

来源：

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 04期

关键词：

Xipamide; RP-HPLC; validation;

D O I：

10.5281/zenodo.1214540

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Xipamide in its pure form as well as in tablet dosage form. Chromatography was carried out on Symmetry C18 (4.6x150 mm, 5 mu) column using a mixture of Acetonitrile:Water (50:50v/v)as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245nm. The retention time of the Xipamide was 2.4 +/- 0.02min. The method produce linear responses in the concentration range of 10-50 mu g/ml of Xipamide. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

引用

页码：2095 / 2102

页数：8

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